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Wellbutrin drug interactions?
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Wellbutrin drug interactions?
Feb 12, 2023 · Learn about interactions between Wellbutrin and other drugs, alcohol, vitamins, foods, supplements, and more. Jul 1, 2024 · Drug Interactions. Take a look at more than a dozen interactive websites that can inspire your own design. Bupropion gets into breast milk in small amounts. Applies to: Wellbutrin (bupropion) and trazodone. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also. (CYP2B6) isoenzyme. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. Angle closure glaucoma Mixed/manic episode Weight loss. Wellbutrin may cause seizures, especially in people with certain medical conditions or when using certain drugs. Longs Drug CVS in Honolulu is a well-known and trusted pharmacy chain that offers a wide range of services and products to meet the needs of its customers. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Are you in need of a convenient and reliable pharmacy? Look no further than Shoppers Drug Mart. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures. View detailed information regarding this drug interaction. View detailed information regarding this drug interaction. There are 498 drugs known to interact with bupropion, along with 7 disease interactions, and 1 alcohol/food interaction. This can cause dizziness, confusion, uneven heartbeats, and chest pain. There are two case reports of seizures in 6-month-old babies exposed to bupropion through breast milk. This can cause dizziness, confusion, uneven heartbeats, and chest pain. One crucial piece of information that can help in this process is the drug imprint code Are you in search of a reliable pharmacy in New Liskeard? Look no further than Finley Drugs. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Includes side effects, dose, interactions and indications. Applies to: Wellbutrin (bupropion) and 12 Hour Nasal Decongestant Spray (oxymetazoline nasal) Both buPROPion and oxymetazoline nasal can increase blood pressure. The risk of other side effects such as drowsiness, dizziness, lightheadedness, fainting, headache, palpitations, and heart rate changes may also increase. You may need a dose adjustment or need your blood pressure checked. Learn about interactions between Wellbutrin and other drugs, alcohol, vitamins, foods, supplements, and more. View detailed information regarding this drug interaction. The relevance of a particular drug interaction to a specific individual is difficult to determine. Applies to: Wellbutrin XL (bupropion) and trazodone. You may need a dose adjustment or need your blood pressure checked. Google and Levi’s are teaming up to create interactive clothing. Sustained-release (SR), film-coated bupropion hydrochloride tablets (e, Wellbutrin SR): Initially, administer orally once daily in the morning, then increase to twice daily, in the morning and evening. This will help your prescriber assess for potential drug interactions. Drug development is a complex and time-consuming process that requires meticulous attention to detail and adherence to stringent regulations. Precautions This medication is used to treat depression. These medicines may also interact with certain foods or diseases. However, as this interactive tool points out, it can be all too easy to slip into an echo c. Not all drugs interact, and not every interaction means you must stop taking one of your medications. Learn about human interaction with geysers. Applies to: Wellbutrin (bupropion) Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. It is uncertain whether a drug interaction was involved. Applies to: Wellbutrin (bupropion) Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. One such resource that has gained significant po. There are 498 drugs known to interact with Wellbutrin XL (bupropion), along with 7 disease interactions, and 1 alcohol/food interaction. Does baclofen interact with my other drugs? Enter other medications to view a detailed report buPROPion food. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure or heart disease. Moderate Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. The go-to treatment for seasonal affective disorder is light therapy. Learn about interactions between Wellbutrin and other drugs, alcohol, vitamins, foods, supplements, and more. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Of the total drug interactions, 218 are major, 275 are moderate, and 5 are minor. View detailed information regarding this drug interaction. Avoid or Use Alternate Drug. Includes side effects, dose, interactions and indications. Wellbutrin (bupropion) Wellbutrin XL (bupropion) Xanax (alprazolam) Zinc (zinc sulfate) Zofran (ondansetron) Zoloft (sertraline) The risk of other side effects such as drowsiness, dizziness, lightheadedness, fainting, headache, palpitations, and heart rate changes may also increase. Center for Drug Evaluation and Research (CDER), US Department of Health and Human Services Food and Drug Administration, Silver Springs, MD; 2020. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Wellbutrin XL (bupropion) Xanax (alprazolam) Zofran (ondansetron) Zoloft (sertraline) Zyrtec (cetirizine) Cannabis alcohol/food interactions The relevance of a particular drug interaction to a specific individual is difficult to determine. Applies to: Wellbutrin (bupropion) Using buPROPion and nicotine together can cause an increase in blood pressure. If you take both medications together, tell your doctor if you have any of these symptoms. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. This can cause dizziness, confusion, uneven heartbeats, and chest pain. See what others have said about Wellbutrin SR (Oral), including the effectiveness, ease of use. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Statins are widely used in cardiovascular disease (CVD) as a common lipid-lowering drug, while quinolones are widely used for the treatment of infectious diseases. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. View detailed information regarding this drug interaction. This drug can interact with other medications and some. Always consult your healthcare provider before starting or stopping any medication. At Google’s developer conference today, the Mountain Vie. Naltrexone may cause liver problems, and using it with other medications that can also affect the liver such as buPROPion may increase that risk. I blacked them out in order to. Moderate Applies to: Wellbutrin (bupropion) Using buPROPion and nicotine together can cause an increase in blood pressure. If you take both medications together, tell your doctor if you have any of these symptoms. If you take both medications together, tell your doctor if you have any of these symptoms. These medicines may also interact with certain foods or diseases. You may need a dose adjustment or need your blood. amazon free return drop off near me This may increase nervous system side effects such as drowsiness, anxiety, depression, and seizures. Find out about possible interactions with alcohol, other drugs, supplements, foods, and more. Understand the potential interactions between Phentermine, a weight loss drug, and Wellbutrin, an antidepressant. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug. Display complete list of interactions for an individual item by clicking item name. If you take both medications together, tell your doctor if you have any of these symptoms. Bupropion works by helping to restore the balance of certain natural substances ( dopamine, norepinephrine) in the brain Find patient medical information for Wellbutrin XL oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Applies to: Wellbutrin (bupropion) and citalopram. Applies to: Wellbutrin XL (bupropion) and losartan. Irregular heart rhythm problems may be serious and potentially life-threatening, although it is a rare side effect. buPROPion food. You may need a dose adjustment or need your blood pressure checked. buPROPion food. Wellbutrin XL (bupropion) Zofran (ondansetron) Zyrtec (cetirizine) Baclofen Interactions. Find out about possible interactions with alcohol, other drugs, supplements, foods, and more. You can also find out when to avoid Wellbutrin. Drug Interactions. The ability to look up information about medications in mere seconds is empowering, with many Americans taking full advantage of the internet to put health information in their han. There are three main options: Private rehab, government-funded rehab. You should avoid or limit the use of alcohol while being treated with these medications. pink adderall 20 mg If you take both medications together, tell your doctor if you have any of these symptoms. You should avoid or limit the use of alcohol while being treated with venlafaxine. Find out about possible interactions with alcohol, other drugs, supplements, foods, and more. Wellbutrin (bupropion) Wellbutrin XL (bupropion) Xanax (alprazolam) Zinc (zinc sulfate) Zofran (ondansetron) Zoloft (sertraline) The risk of other side effects such as drowsiness, dizziness, lightheadedness, fainting, headache, palpitations, and heart rate changes may also increase. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. For non-prescription products, read the label or package ingredients carefully Apr 23, 2024 · Bupropion is used to treat major depressive disorder, seasonal affective disorder and to help people stop smoking. Jul 1, 2024 · Drug Interactions. You can also find out when to avoid Wellbutrin. Allergies. Does doxepin interact with my other drugs? Enter other medications to view a detailed report Add a drug to check. Some people may also experience impairment in thinking and judgment. It helps regulate your mood by increasing norepinephrine and dopamine hormones in your brain This list may not describe all possible interactions. In this article, we will explore a collection of interactive C program examples that w. You should avoid or limit the use of alcohol. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. On the other hand, sudden withdrawal from alcohol following regular or chronic use can. buPROPion food. And using them together may have additive effects. Practitioners should be aware of potentially significant drug interactions with the use of antidepressants in order to effectively prevent or manage adverse events while optimizing. This can cause dizziness, confusion, uneven heartbeats, and chest pain. In addition, buPROPion can increase the blood levels of traZODone, which may increase other side effects. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked. phentermine food. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. eucharistic miracle poland debunked A Moderate Drug Interaction exists between tamsulosin and Wellbutrin. buPROPion phenylephrine. In these cases, your doctor may want to change the dose, or other precautions may be necessary. View detailed information regarding this drug interaction. For non-prescription products, read the label or package ingredients carefully Apr 23, 2024 · Bupropion is used to treat major depressive disorder, seasonal affective disorder and to help people stop smoking. This can increase side effects such as dizziness, dry mouth, loss of appetite, sleep disturbances, and heart palpitations. These classifications are only a guideline. Additionally, approximately 13% of. View drug interactions between hydroxyzine and Wellbutrin XL. Of the total drug interactions, 218 are major, 275 are moderate, and 5 are minor. This can cause dizziness, confusion, uneven heartbeats, and chest pain. Talk to your doctor or pharmacist if you have. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Jul 1, 2024 · Drug Interactions. Applies to: Wellbutrin (bupropion) and DayQuil / NyQuil Severe Cold and Flu (acetaminophen / dextromethorphan / doxylamine / guaifenesin / phenylephrine) Both buPROPion and phenylephrine can increase blood pressure. Days 1 to 3: Take 1 tablet (150 mg) each day. View detailed information regarding this drug interaction. Liberty Interactive News: This is the News-site for the company Liberty Interactive on Markets Insider Indices Commodities Currencies Stocks iOS: Fantastical 2 for iPad and iPhone were both updated today to include a bunch of new iOS 8 features, including interactive notifications, a today widget, and more Human Interaction with Geysers - Human interaction with geysers is explained in this section. Does bupropion interact with my other drugs? Enter other medications to view a detailed report.
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A Moderate Drug Interaction exists between diazepam and Wellbutrin SR. Major: Highly clinically significant. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk. Includes side effects, dose, interactions and indications. For non-prescription products, read the label or package ingredients carefully Apr 23, 2024 · Bupropion is used to treat major depressive disorder, seasonal affective disorder and to help people stop smoking. See more drug interactions. In addition, buPROPion can increase the blood levels of DULoxetine, which may increase other side effects. buPROPion food. A Major Drug Interaction exists between Fetzima and Wellbutrin. Precautions This medication is used to treat depression. The Australian Adverse Drug Reaction Advisory Committee reported that 268 of the 780 reports it received in association with bupropion through mid-May 2001 involved nervous system disorders. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Applies to: Wellbutrin (bupropion) Using buPROPion and nicotine together can cause an increase in blood pressure. An estimated 50% of people aged 12 and over have used an illicit drug at least one time. Of the total drug interactions, 218 are major, 275 are moderate, and 5 are minor. Applies to: Wellbutrin (bupropion) Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Jan 23, 2023 · Wellbutrin is a prescription drug used to treat depression in adults. adriana maya For non-prescription products, read the label or package ingredients carefully Apr 23, 2024 · Bupropion is used to treat major depressive disorder, seasonal affective disorder and to help people stop smoking. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. Does metaxalone interact with my other drugs? Enter other medications to view a detailed report Bupropion Pregnancy Warnings. This can cause dizziness, confusion, uneven heartbeats, and chest pain. There are 498 drugs known to interact with Wellbutrin XL (bupropion), along with 7 disease interactions, and 1 alcohol/food interaction. Includes side effects, dose, interactions and indications. View detailed information regarding this drug interaction. It's also available as a generic drug Examples of drugs that can cause interactions. Ticlopidine and Clopidogrel: Concomitant treatment with these drugs can increase bupropion exposure but decrease hydroxybupropion. Practitioners should be aware of potentially significant drug interactions with the use of antidepressants in order to effectively prevent or manage adverse events while optimizing. There are 716 drugs known to interact with amiodarone, along with 10 disease interactions, and 1 alcohol/food interaction. Trintellix (vortioxetine) is a prescription oral tablet used to treat depression. The drugs listed below may potentially affect Wellbutrin's effectiveness and potentially cause adverse reactions. View detailed information regarding this drug interaction. Get emergency medical help if you have signs of an allergic reaction (hives, itching, fever, swollen glands, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling) Report any new or worsening symptoms to your doctor, such as: mood or behavior. You may need a dose adjustment or need your blood pressure checked. See more drug interactions. pretty instagram baddies Treatment of depression often requires long-term management with medication. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. iOS: Fantastical 2 for iPad and iPhone were both updated today to include a bunch of new iOS 8 features, including interactive notifications, a today widget, and more Human Interaction with Geysers - Human interaction with geysers is explained in this section. You should avoid or limit the use of alcohol while being. Does doxepin interact with my other drugs? Enter other medications to view a detailed report Add a drug to check. Taking bupropion while breastfeeding is not expected to cause harmful effects for most breastfed infants. View detailed information regarding this drug interaction. Learn about human interaction with geysers. Precautions This medication is used to treat depression. Applies to: bupropion and Ingrezza (valbenazine) BuPROPion may increase the blood levels and effects of valbenazine, such as sleepiness and an irregular heart rhythm problem called QT prolongation. Single-dose studies in healthy volunteers given bupropion and alcohol failed to demonstrate either a significant pharmacokinetic or pharmacodynamic interaction. Of the total drug interactions, 218 are major, 275 are moderate, and 5 are minor. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. A Major Drug Interaction exists between diethylpropion and Wellbutrin. Moderate Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Bupropion works by helping to restore the balance of certain natural substances ( dopamine, norepinephrine) in the brain Find patient medical information for Wellbutrin XL oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Includes side effects, dose, interactions and indications. Metaxalone Interactions. If you take both medications together, tell your doctor if you have any of these symptoms. mystiqueanimeart Feb 12, 2023 · Learn about interactions between Wellbutrin and other drugs, alcohol, vitamins, foods, supplements, and more. Moderate Applies to: Wellbutrin (bupropion) Using buPROPion and nicotine together can cause an increase in blood pressure. See what others have said about Wellbutrin SR (Oral), including the effectiveness, ease of use. Therefore, the potential exists for drug interactions between WELLBUTRIN and drugs that are inhibitors or inducers of CYP2B6. The relevance of a particular drug interaction to a specific individual is difficult to determine. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. For faster sleep onset, zolpidem should not be taken with or immediately after a meal. Bupropion Interactions. Does bupropion interact with my other drugs? Enter other medications to view a detailed report. Talk to your doctor before using buPROPion together with citalopram. Some people may also experience impairment in thinking and judgment. Bupropion works by helping to restore the balance of certain natural substances ( dopamine, norepinephrine) in the brain Find patient medical information for Wellbutrin XL oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. A Major Drug Interaction exists between Fetzima and Wellbutrin.
See more drug interactions. digestive side effects, including constipation and nausea* weight gain*. Talk to your doctor or pharmacist if you have. Wellbutrin is a type of antidepressant. Drug Interactions. Hypertension management: The two medicines are equally effective in lowering blood pressure in the short term, but atenolol's effects last longer. binghamton pets craigslist You may need a dose adjustment or need your blood pressure checked more often if you take both medications. Talk to your doctor before using buPROPion together with citalopram. Applies to: Wellbutrin XL (bupropion) Using buPROPion and nicotine together can cause an increase in blood pressure. There are 498 drugs known to interact with bupropion, along with 7 disease interactions, and 1 alcohol/food interaction. However, the dose is usually not more than 300 mg per day. ambetter physicians Taking bupropion while breastfeeding is not expected to cause harmful effects for most breastfed infants. Precautions This medication is used to treat depression. Wellbutrin SR (Oral) received an overall rating of 8 out of 10 stars from 8 reviews. If you take both medications together, tell your doctor if you have any of these symptoms. Moderate Food Interaction. You may need a dose adjustment or need your blood pressure checked. best pimple popping videos on youtube Two drugs can have a synergistic effect if they increase each other’s effectiveness when taken together. Applies to: Wellbutrin XL (bupropion) and naltrexone. There are 498 drugs known to interact with Wellbutrin XL (bupropion), along with 7 disease interactions, and 1 alcohol/food interaction. The maximum dosage of Wellbutrin SR is 400 mg per day. You may need a dose adjustment or need your blood pressure checked.
One of the primary reaso. And using them together may have additive effects. Learn about interactions between Wellbutrin and other drugs, alcohol, vitamins, foods, supplements, and more. These medicines may also interact with certain foods or diseases. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. Major: Highly clinically significant. Bupropion works by helping to restore the balance of certain natural substances ( dopamine, norepinephrine) in the brain Find patient medical information for Wellbutrin XL oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Following a single dose in humans, peak plasma concentrations of hydroxybupropion occur Applies to: clonidine and Wellbutrin (bupropion) CloNIDine and buPROPion may have additive effects in lowering your blood pressure. One such resource that has gained significant po. Dosages >150 mg should be administered as divided doses twice daily, with ≥8 hours separating the doses. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. Call your doctor immediately if you have fever, chills. buPROPion food. Of the total drug interactions, 218 are major, 275 are moderate, and 5 are minor. Does bupropion interact with my other drugs? Enter other medications to view a detailed report. In these cases, your doctor may want to change the dose, or other precautions may be necessary. A Moderate Drug Interaction exists between Paxlovid and Wellbutrin. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. In these cases, your doctor may want to change the dose, or other precautions may be necessary. One of the primary reaso. Of the total drug interactions, 35 are major, and 277 are moderate. milly bobby brown rule 34 Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Of the total drug interactions, 218 are major, 275 are moderate, and 5 are minor. Feb 12, 2023 · Learn about interactions between Wellbutrin and other drugs, alcohol, vitamins, foods, supplements, and more. This can cause dizziness, confusion, uneven heartbeats, and chest pain. buPROPion valbenazine. In addition, with certain long-acting forms of methylphenidate, alcohol can cause too much of the drug to be released at one time. Bupropion works by helping to restore the balance of certain natural substances ( dopamine, norepinephrine) in the brain Find patient medical information for Wellbutrin XL oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Wellbutrin is a prescription drug used to treat depression in adults. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Of the total drug interactions, 27 are major, 339 are moderate, and 1 is minor. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Feb 12, 2023 · Learn about interactions between Wellbutrin and other drugs, alcohol, vitamins, foods, supplements, and more. Bupropion works by helping to restore the balance of certain natural substances ( dopamine, norepinephrine) in the brain Find patient medical information for Wellbutrin XL oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Drug Interactions. Using buPROPion and nicotine together can cause an increase in blood pressure. A Moderate Drug Interaction exists between verapamil and Wellbutrin. See more drug interactions. Learn about human interaction with geysers. If you take both medications together, tell your doctor if you have any of these symptoms. These medicines may also interact with certain foods or diseases. ken nunn Of the total drug interactions, 218 are major, 275 are moderate, and 5 are minor. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Wellbutrin was used to relieve the symptoms of depression in Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). You may need a dose adjustment or need your blood pressure checked. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. However, as this interactive tool points out, it can be all too easy to slip into an echo c. Does bupropion interact with my other drugs? Enter other medications to view a detailed report. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Moderate Food Interaction. After 4 days, your doctor might increase your dosage to 300 mg once per day. A Major Drug Interaction exists between oxycodone and Wellbutrin. The starting dosage of Wellbutrin XL is 150 mg once per day. A Major Drug Interaction exists between Pristiq and Wellbutrin.